Post List

Useful Techniques

How to Remove Triphenylphosphine Oxide (TPPO)

SHP2

SHP2 Inhibitors in Clinical Trials
The Discovery of TNO155
The Process Chemistry of TNO155
The Discovery of IACS-15414

KRAS

KRAS2 Inhibitors in Clinical Trials
The Synthesis/Isolation of Atropisomers

Degraders

Protein Degraders in Clinical Trials

RAF Inhibitors

Approved and Clinical-Stage RAF Inhibitors

Reactions

Byproduct Profile of Vestipitant (GW597599) during Urea Formation
Sodium Cyanoborohydride Mediated Reduction
Sodium Triaceoxyborohydride Mediated Reductive Amination
Tetrabutylammonium Cyanoborohydride as a Reducing Agent
Borane Pyridine Mediated Reductive Amination
Borane Picoline and 5-Ethyl-2-MethylPyridine Borane Mediated Reductive Amination

MEK inhibitors

Approved and Clinical-Stage MEK Inhibitors

ERK inhibitors

Approved and Clinical-Stage ERK Inhibitors

Buchwald Reaction

Buchwald-Type Ligands
BrettPhos
XPhos
Buchwald Coupling Ligand selection Flow Chart

Ligands

Biaryl Based Bidentate Phosphine Ligands​
Ferrocenyl Based Phosphine Ligands

API

Crystallization Process Development of Serabelisib (TAK117)
Quench-Crystallization Development for an Intermediate of the Synthesis of Sotorasib